Clinical Trials

Sarcomas are rare. There are many types and they are difficult to study. The MUHC is known as a major center studying these tumors. We work on curing, diminishing the occurrence of complications and understanding how physical capacities and quality of life are affected. During your different visits, it is possible that you will be asked to participate to different projects, experimental or not. A voluntary participation contributes to the improvement of knowledge and to the development of better care.

We have a wide range of clinical trials ongoing at our research facility. Please see the list below to find more informations about each trials.

 

CHEMOTHERAPY/TARGETED THERAPY/IMMUNOTHERAPY

 

  1. Study of DCC-3014 in Patients With Advanced Tumors and Tenosynovial Giant Cell Tumor https://clinicaltrials.gov/ct2/show/NCT03069469?term=dcc&cond=TGCT&draw=2&rank=1
  2. Tazemetostat in Combination With Doxorubicin as Frontline Therapy for Advanced Epithelioid Sarcoma https://clinicaltrials.gov/ct2/show/NCT04204941?cond=tazemetostat&draw=6&rank=8

 

RADIOTHERAPY

 

  1. Short Course Pre-operative RadiothErapy for Soft Tissue SarcOmas – a Phase I/II trial (PRESTO)
  2. Radiomics for prediction of outcome in sarcoma
  3. Development of mixed photon-electron radiotherapy for sarcoma
  4. Hypofractionation for pre operative radiotherapy for extremity sarcoma
  5. A Randomized Trial of Pembrolizumab & Radiotherapy Versus Radiotherapy in High-Risk Soft Tissue Sarcoma of the Extremity (SU2C-SARC032)  https://clinicaltrials.gov/ct2/show/NCT03092323

 

BIOBANK

 

  1. Interdisciplinary Health Research Team in Musculoskeletal Neoplasia
  2. Oncology repository for children and young adults (ORCYD)
  3. Canadian Sarcoma Research and Clinical Collaboration (CanSaRCC)

 

SURGERY

 

  1. Prophylactic Antibiotic Regimens in Tumour Surgery (PARITY): A Multi-Center Randomized Controlled Study Comparing Alternative Antibiotic Regimens in Patients Undergoing Tumour Resections with Endoprosthetic Replacements https://clinicaltrials.gov/ct2/show/NCT01479283?term=PARITY&draw=2&rank=1
  2. Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone https://clinicaltrials.gov/ct2/show/NCT03295981
  3. The Effect of Incisional Negative Pressure Wound Therapy on Wound Complications and Clinical Outcomes Following Lower Extremity Sarcoma Surgery in Patients treated with Preoperative Radiation Therapy: A Multicenter Randomized Controlled Trial https://clinicaltrials.gov/ct2/show/NCT03175718?cond=Sarcoma&map_cntry=CA&draw=3&rank=13
  4. Surveillance AFter Extremity Tumor surgerY (SAFETY) International Randomized Controlled Trial https://clinicaltrials.gov/ct2/show/NCT03944798
  5. REtroperitoneal SArcoma Registry: an International Prospective Initiative (RESAR) https://clinicaltrials.gov/ct2/show/NCT03838718?term=RESAR&draw=2&rank=1

  6. Defining the Patient Experience in Extremity Soft Tissue Sarcoma Through a Sequential Exploratory Mixed Methods Approach: The Sarcoma- Specific Quality of Life (SARCQOL) Study.
  7. Starting recovery pre-operatively: Feasibility of implementing individualized prehabilitation for people scheduled for lower limb soft-tissue sarcoma surgery.
  8. Merkel Cell Cancer Pan-Canadian Collaborative  

 

COVID-19

 

  1. Neo-adjuvant Radiation Therapy in the Treatment of Retroperitoneal Sarcoma in times of COVID-19
  2. Outcomes of elective cancer surgery during the COVID-19 pandemic crisis: a single center experience
  3. Covid is bad, cancer is worse. Decision making in orthopaedic oncology surgery during COVID-19. An international survey.

 

RETROSPECTIVE STUDIES

 

  1. Diagnosis, Treatment and Management of Spermatic Cord Sarcomas: a Tertiary Center Experience
  2. Predictive value of neutrophil to lymphocyte ratio in soft-tissue Sarcoma: A North American perspective Lymphadenectomy in Surgical Oncology: good, better, best
  3. Does increased distance from medical care affect outcomes? An analysis of urban-rural disparities in patients with retroperitoneal Sarcomas in Quebec
  4. Retrospective study of sensitivity of myxofibrosarcoma to chemotherapy

 

PSYCHOLOGY

  1. Understanding recovery and participation in patients with bone and soft tissue sarcoma