Fundamental Research

Our research aims to unravel the genetic bases of cancer recurrence and metastasis in cancers such as sarcomas and brain tumours. We are focused on understanding how gene function is altered during the process of metastasis initiation, maintenance and progression. Ultimately, we hope to contribute to finding efficacious ways to cure and prevent sarcomas.


  • A model of recurrent metastatic osteosarcoma based on patient derived xenografts
  • In vivo functional genomics of Ewing’s Sarcoma to reveal drivers of metastatic relapse
  • Mutational analysis of Hedgehog Signaling Pathway Genes in Human Solitary Fibrous Tumours
  • Deciphering metastasis maintenance events in adolescent and young adult Sarcoma
    Contact: Dr. Livia Garzia at